5-Amino-1MQ
5-Amino-1MQ is a small-molecule NNMT inhibitor studied in preclinical models for fat reduction and metabolic flexibility; research-product protocols typically use 50 mg orally daily, within a 50-150 mg range.
Studied in preclinical (rodent and cell-based) models for NNMT inhibition, white-adipose fat reduction, increased energy expenditure, and NAD+/metabolic-flexibility pathways, with interest in preserving lean mass.
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme highly expressed in white adipose tissue and liver. It is a methylquinolinium compound, not a peptide despite its frequent grouping with research peptides. NNMT normally consumes nicotinamide and the universal methyl donor S-adenosylmethionine (SAM) to produce 1-methylnicotinamide (1-MNA) — a reaction researchers describe as a 'methyl sink' that can divert substrate away from NAD+ salvage.
By occupying the NNMT active site, 5-Amino-1MQ has been shown in preclinical work to lower intracellular 1-MNA while raising NAD+ and SAM and suppressing lipogenesis in adipocytes. In diet-induced obese mice it has been studied for reduced body weight and white adipose mass without changing food intake. It is not FDA-approved and is handled as a research compound; no published human clinical trials currently characterize its safety or efficacy.
In published animal research it has been administered by injection, while consumer research-product protocols commonly reference daily oral capsules in the ~50-100 mg range; no controlled human dosing has been established.
Preclinical studies reported measurable reductions in body weight and adipose mass over roughly an 11-day dosing course in mice; no validated human time-to-effect exists.
In research and informal protocols it is often discussed alongside NAD+ precursors (e.g., NMN or NR) and GLP-1-class or growth-hormone-secretagogue compounds, though no combination has been clinically validated.
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This page is educational reference material about compounds studied in research settings. It is not medical advice, and nothing here is a recommendation to buy, possess, or use any compound. Research findings described are from published literature; individual compounds may not be approved for human use. Talk to a licensed clinician about anything that affects your health.