ARA-290
ARA-290 (cibinetide) is a synthetic 11-amino-acid non-erythropoietic peptide modeled on EPO's helix B that activates the innate repair receptor, studied for small-fiber neuropathy and tissue repair; research protocols typically use 1.5 mg daily subcutaneously, 5 days on/2 off.
It has been studied primarily for small-fiber neuropathy and neuropathic pain (notably in sarcoidosis and type 2 diabetes), with broader research interest in its anti-inflammatory and tissue-repair signaling.
ARA-290 (cibinetide) is a synthetic 11-amino-acid peptide modeled on helix B of erythropoietin (EPO) — the region of the EPO molecule that engages tissue-protective signaling rather than red-blood-cell production. Unlike EPO, it has been engineered to be non-erythropoietic: research describes it selectively activating the so-called innate repair receptor (IRR), a heterocomplex of the EPO receptor and the beta-common receptor (CD131) belonging to the type I cytokine receptor family. Through this pathway, studies have characterized anti-inflammatory and cytoprotective effects, including reductions in neuropathic pain and increases in small nerve fiber density (corneal and intraepidermal) in early-phase human research.
ARA-290 is not FDA-approved; it remains an investigational research compound studied in Phase 2 trials and used as a research chemical, and is not an approved therapy for any condition.
Published research has most often used subcutaneous administration, with controlled trials studying roughly 1-8 mg per day (commonly 4 mg) for about 28 days, while an earlier pilot used 2 mg intravenously three times weekly.
In clinical research, neuropathic symptom and nerve-fiber changes were typically assessed over a roughly 28-day dosing course, with some symptom improvements reported during that period.
In research and anecdotal protocols it is sometimes discussed alongside other recovery- and repair-oriented peptides such as BPC-157 and TB-500, though controlled combination data are limited.
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This page is educational reference material about compounds studied in research settings. It is not medical advice, and nothing here is a recommendation to buy, possess, or use any compound. Research findings described are from published literature; individual compounds may not be approved for human use. Talk to a licensed clinician about anything that affects your health.