Cagrisema
CagriSema is an investigational fixed-dose combination of the amylin analog cagrilintide and the GLP-1 agonist semaglutide, studied for weight reduction; research protocols typically use 2 mg weekly subcutaneously (titrating toward 6 mg).
It has been studied for body-weight reduction in adults with overweight or obesity, including those with type 2 diabetes, leveraging dual amylin- and GLP-1-pathway appetite suppression.
CagriSema is an investigational fixed-dose combination of two peptide analogues: cagrilintide, a long-acting amylin analogue (characterized as a dual amylin and calcitonin receptor agonist), and semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist. The two components are designed to act on distinct but complementary appetite-regulating pathways — cagrilintide engages amylin/calcitonin receptors in brainstem and hypothalamic circuits to promote satiety and slow gastric emptying, while semaglutide acts on GLP-1 receptors to reduce appetite, slow gastric emptying, and modulate glucose-dependent insulin and glucagon secretion. 4 mg) for body-weight reduction in adults with overweight or obesity, with and without type 2 diabetes.
CagriSema is not FDA-approved; Novo Nordisk submitted a New Drug Application in December 2025, and as of this writing it remains an investigational combination under regulatory review.
In Phase 3 research it was administered as a once-weekly subcutaneous injection of a fixed-dose combination (cagrilintide 2.4 mg plus semaglutide 2.4 mg), typically reached through gradual dose titration over several weeks.
Research reports gradual, progressive weight reduction over the course of treatment, with trial endpoints assessed at 68 weeks rather than an immediate effect.
As a fixed combination it already pairs an amylin analogue (cagrilintide) with a GLP-1 receptor agonist (semaglutide), and in research contexts it is studied alongside lifestyle and dietary intervention rather than stacked with additional agents.
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