CJC-1295 (no DAC)
CJC-1295 (no DAC), also called Modified GRF (1-29), is a short-acting synthetic GHRH analog studied for stimulating pulsatile GH and IGF-1 release; research protocols typically use around 100 mcg subcutaneously, often twice daily.
It has been studied in research settings as a GHRH analog for stimulating pulsatile endogenous growth hormone and IGF-1 secretion, with interest in muscle, fat metabolism, and recovery contexts.
CJC-1295 (no DAC) — also known as Modified GRF (1-29) or Mod GRF 1-29 — is a synthetic 29-amino-acid analog of growth hormone-releasing hormone (GHRH), corresponding to the first 29 residues of native GHRH. It carries four amino acid substitutions (positions 2, 8, 15, and 27) engineered to resist enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4), extending its functional life beyond that of native GHRH while preserving receptor binding. Research characterizes it as acting on GHRH receptors on somatotroph cells of the anterior pituitary, where it has been studied for stimulating endogenous growth hormone (GH) release in a pulsatile pattern that more closely mimics natural secretion.
Unlike the DAC-conjugated version (which binds albumin for a multi-day half-life), the no-DAC form is short-acting. CJC-1295 is not FDA-approved; the parent compound was an investigational drug abandoned after early-phase trials and it is used today as a research compound only.
In research literature the no-DAC form is typically described as administered subcutaneously, often in microgram-scale doses given one or more times daily (frequently around or before sleep), reflecting its short duration and pulsatile profile.
Research describes a rapid, short-lived GH pulse following subcutaneous administration, with the compound's brief plasma presence producing an acute response rather than sustained elevation.
It is most commonly studied stacked with a growth hormone secretagogue such as Ipamorelin, which acts on a complementary pathway to amplify the GH pulse.
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This page is educational reference material about compounds studied in research settings. It is not medical advice, and nothing here is a recommendation to buy, possess, or use any compound. Research findings described are from published literature; individual compounds may not be approved for human use. Talk to a licensed clinician about anything that affects your health.