Dihexa
Dihexa is a synthetic angiotensin-IV-derived oligopeptide studied in preclinical models as a potent cognitive enhancer acting via the HGF/c-Met pathway; research protocols typically use roughly 8 mg orally daily (range 8-40 mg).
Has been studied in preclinical and animal models for cognition, synaptogenesis, and Alzheimer's-disease-like memory impairment via the HGF/c-Met pathway.
Dihexa (developmental code PNB-0408; N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) is a small synthetic oligopeptide derived from angiotensin IV (AngIV). Despite its AngIV origin, research indicates it does not act primarily through classic angiotensin receptors; instead it has been characterized as an allosteric modulator of the hepatocyte growth factor (HGF) / c-Met system. Studies report it binds HGF with high affinity (reported Kd ~65 pM) and potentiates HGF-dependent phosphorylation of the c-Met receptor at subthreshold HGF concentrations, an activity linked in cell and rodent models to dendritic spinogenesis and synaptogenesis.
In neurotrophic assays it has been described as several orders of magnitude more potent than brain-derived neurotrophic factor (BDNF) as a comparative benchmark. Dihexa is reported to be orally active and blood-brain-barrier permeable. It is not FDA-approved; it is an experimental research compound, while its phosphate prodrug fosgonimeton has been studied in clinical trials for neurodegenerative conditions.
In the founder's handbook protocol it is taken as an oral preparation, approximately 10 mg two to three times per week; published human dosing standards do not exist as it remains a research compound.
Onset in humans is not established; rodent studies have reported cognitive and synaptogenic effects over days of repeated dosing rather than acutely.
In nootropic research-community use it is often discussed alongside other cognitive or neurotrophic compounds, but no clinically validated stacking combinations have been established.
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This page is educational reference material about compounds studied in research settings. It is not medical advice, and nothing here is a recommendation to buy, possess, or use any compound. Research findings described are from published literature; individual compounds may not be approved for human use. Talk to a licensed clinician about anything that affects your health.