Ipamorelin + CJC-1295
Ipa/CJC is a research blend of the growth-hormone secretagogues Ipamorelin and CJC-1295 (no DAC) studied for stimulating endogenous GH and IGF-1 secretion; research protocols typically start near 100 mcg of each subcutaneously at bedtime, building toward ~300 mcg each.
It has been studied as a research tool for stimulating endogenous growth-hormone and IGF-1 secretion, with interest in body-composition, recovery, and GH/IGF-axis research contexts.
Ipa/CJC is a research blend of two growth-hormone secretagogues that act through complementary pituitary pathways. Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and a selective agonist of the ghrelin / growth-hormone-secretagogue receptor (GHSR-1a); research has characterized it as one of the most selective secretagogues, stimulating pulsatile GH release without the cortisol, ACTH, or prolactin elevations seen with earlier compounds. CJC-1295 (no DAC), also known as modified GRF 1-29, is a synthetic analog of the first 29 amino acids of growth-hormone-releasing hormone (GHRH) that binds the GHRH receptor on somatotrophs and raises intracellular cAMP.
Combining a GHRH analog with a ghrelin-receptor agonist has been studied as a way to amplify endogenous GH output through two distinct receptors. Neither component is FDA-approved; both are handled as research compounds, and human data remain limited compared with preclinical work.
In research settings the blend is typically administered by subcutaneous injection, often once or more daily and frequently timed before sleep, with the no-DAC form chosen for its short half-life to approximate natural pulsatile GH release.
Research on the secretagogues reports a rapid rise in plasma GH within roughly 30 to 60 minutes of administration, while changes in downstream markers such as IGF-1 are studied over days to weeks.
It is commonly combined as the Ipamorelin and CJC-1295 (no DAC) pairing itself, and in research discussions is sometimes considered alongside other GH-axis or recovery-oriented peptides.
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This page is educational reference material about compounds studied in research settings. It is not medical advice, and nothing here is a recommendation to buy, possess, or use any compound. Research findings described are from published literature; individual compounds may not be approved for human use. Talk to a licensed clinician about anything that affects your health.