KPV
KPV is a synthetic tripeptide (Lys-Pro-Val) derived from alpha-MSH, studied for gut and systemic inflammation; research protocols typically use 200 mcg daily subcutaneously.
KPV has been studied primarily for gut and systemic inflammation, including animal models of inflammatory bowel disease (colitis), as well as contact dermatitis and other inflammatory conditions.
KPV is a synthetic tripeptide (Lys-Pro-Val) corresponding to the C-terminal sequence (residues 11-13) of alpha-melanocyte-stimulating hormone (alpha-MSH), the body's endogenous melanocortin peptide. Research has characterized KPV as retaining much of alpha-MSH's anti-inflammatory signaling while lacking the pigment-stimulating activity of the full hormone. Mechanistic studies report that KPV is taken up into intestinal epithelial and immune cells via the di/tripeptide transporter PepT1 (which is upregulated in the inflamed colon), where nanomolar concentrations have been shown to inhibit activation of the NF-kappaB and MAP-kinase inflammatory signaling pathways and to reduce secretion of pro-inflammatory cytokines such as TNF-alpha and IL-6.
In rodent models, oral KPV reduced the severity of DSS- and TNBS-induced colitis. KPV is not FDA-approved; it is used as a research compound and is not an approved drug for any indication.
In research settings KPV has been administered orally and via injectable subcutaneous routes, with low (often microgram-to-low-milligram) daily amounts described in non-clinical work; no standardized human dosing is established.
Research has not established a defined human time-to-effect; preclinical inflammation models typically report changes over days of repeated administration rather than acute single-dose effects.
In research and protocol discussions KPV is commonly grouped with gut-repair and recovery peptides such as BPC-157 and TB-500, though combination use has not been formally validated in controlled human studies.
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This page is educational reference material about compounds studied in research settings. It is not medical advice, and nothing here is a recommendation to buy, possess, or use any compound. Research findings described are from published literature; individual compounds may not be approved for human use. Talk to a licensed clinician about anything that affects your health.