Mazdutide
Mazdutide is a synthetic acylated oxyntomodulin analog acting as a dual GLP-1 and glucagon receptor agonist, studied for weight management and glycemic control; research protocols typically use 1 mg weekly subcutaneously (titrating toward 6 mg).
Mazdutide has been studied primarily for chronic weight management in adults with overweight or obesity, and for glycemic control in type 2 diabetes.
Mazdutide (research designations IBI362 and LY3305677) is a synthetic, fatty-acylated peptide analogue of oxyntomodulin, a naturally occurring gut hormone. It is a dual agonist that activates both the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). Research suggests this combined signaling has been studied to suppress appetite and slow gastric emptying via GLP-1R while increasing energy expenditure and influencing hepatic lipid metabolism via GCGR.
The lipidation extends its half-life to support once-weekly dosing. It has been characterized in Phase 3 trials (the GLORY and DREAMS programs) for body-weight reduction and glycemic control in Chinese adults. Mazdutide is not FDA-approved; it has been approved by China's NMPA for chronic weight management and remains a research compound in other markets, including the United States.
Research has typically used once-weekly subcutaneous injection with gradual dose titration over several weeks (for example, escalating toward 4 mg, 6 mg, or 9 mg) to limit gastrointestinal effects.
Research reports gradual effects, with appetite changes observed within the first weeks and progressive body-weight reduction continuing over many months, with some trials not yet reaching a weight plateau by study end.
In research and protocol contexts it is generally used on its own rather than stacked, though it has been studied alongside lifestyle and dietary interventions and compared head-to-head with single GLP-1 agonists such as semaglutide.
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This page is educational reference material about compounds studied in research settings. It is not medical advice, and nothing here is a recommendation to buy, possess, or use any compound. Research findings described are from published literature; individual compounds may not be approved for human use. Talk to a licensed clinician about anything that affects your health.