NAD+
NAD+ is the injectable form of nicotinamide adenine dinucleotide, a coenzyme central to mitochondrial energy production, DNA repair, and sirtuin-driven longevity signaling; research protocols typically start at 25 mg subcutaneously every other day (titrating toward 150 mg).
Adults seeking cellular-energy or longevity-oriented support, particularly those with declining metabolic resilience, slower recovery, or chronic-fatigue patterns
NAD+ (Nicotinamide Adenine Dinucleotide) is one of the most fundamental coenzymes in cellular biology. It's required for electron transport in mitochondrial ATP production, DNA repair via PARP enzymes, and the activity of sirtuins (a family of NAD+-dependent enzymes implicated in longevity signaling). Cellular NAD+ levels decline measurably with age, dropping by roughly 50% between ages 40 and 60 in human tissue analyses.
This decline correlates tightly with reduced mitochondrial function, slower DNA repair, dysregulated metabolic signaling, and many of the cellular hallmarks of aging. Direct NAD+ administration via subcutaneous injection bypasses the gastrointestinal degradation that limits oral NAD+ precursors like nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), delivering the coenzyme into circulation where it can be utilized by tissues with declining endogenous levels. Research applications span energy metabolism support, neurological function (Parkinson's disease, neuropathy), recovery from chronic stressors, addiction recovery (NAD+ has a 50-year history in alcohol detox protocols), and longevity protocols.
The compound is under active human investigation across multiple Phase 2 and Phase 3 trials. Subcutaneous NAD+ administration produces a distinctive flushing sensation in many users (typically warm or itchy across the chest and face, self-limited within minutes, attributed to histamine modulation rather than allergy).
Subcutaneous injection daily or several times per week; dose typically 50-300mg depending on protocol. Subcutaneous administration produces a brief flushing sensation; IV protocols exist but require clinical settings
Energy and recovery changes often reported within 2-4 weeks; longer-term metabolic adaptations develop over months
Frequently combined with NAD+ precursors (NMN, NR) for sustained levels, or with longevity peptides like Epitalon and MOTS-c
Log every dose, count every vial, and verify your batches — free in the goodtides app.
This page is educational reference material about compounds studied in research settings. It is not medical advice, and nothing here is a recommendation to buy, possess, or use any compound. Research findings described are from published literature; individual compounds may not be approved for human use. Talk to a licensed clinician about anything that affects your health.