Selank + Semax
Selank + Semax is a pre-mixed vial pairing two Russian-developed research neuropeptides: Selank (an anxiolytic tuftsin analog) and Semax (a nootropic ACTH(4-10) analog). Documented human research uses each intranasally in the 250-1000 mcg per-administration range. A conservative starting protocol is ~250 mcg of each per day (one nasal administration), assessing response and nasal tolerability before building toward ~500 mcg each. IMPORTANT: these are dosed in MICROGRAMS (mcg), not milligrams — a mg-scale dose would be a 1000x overdose.
Research contexts exploring anxiety/stress modulation together with cognition, focus, working memory and learning. Selank supplies the calming/anxiolytic side (GABA/serotonergic modulation, without sedation or dependence seen with benzodiazepines in the source literature); Semax supplies the stimulating nootropic and neuroprotective side (BDNF/TrkB upregulation, attention and executive-function effects). The blend is aimed at those wanting both a steady-focus and a stress-buffering profile from a single vial.
Selank is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro). In the research literature it produces anxiolytic and mild nootropic effects, modulating GABAergic and serotonergic/monoamine signalling and influencing expression of BDNF and other neurotrophic/immune factors, without the sedation, tolerance, or dependence associated with benzodiazepines. Semax is a synthetic analog of the ACTH(4-10) fragment (Met-Glu-His-Phe-Pro-Gly-Pro) with the biological activity uncoupled from hormonal ACTH effects.
6-fold TrkB phosphorylation in rat studies), plus modulation of dopaminergic and serotonergic systems; peak BDNF upregulation occurs ~3-8 hours post-dose and stays elevated ~24 hours. Together the blend pairs Selank's stress/anxiety modulation with Semax's neurotrophic, attention and neuroprotective actions.
Dosed in MICROGRAMS of EACH component (the vial is 10 mg Selank + 10 mg Semax). Because both peptides share the same documented research range, a single dose figure applies to each. Conservative start: ~250 mcg each, one intranasal administration in the morning, for the first 2-3 days to gauge response and nasal tolerability. Standard: ~500 mcg each daily, which can be split (e.g. morning + midday) since both peptides have very short plasma half-lives. Higher research doses run up to ~1000 mcg each per administration, typically split across the day. Reconstitute 20 mg total (10 mg each) in ~2 mL bacteriophage-free bacteriostatic water; the calculator converts your target mcg-per-component to a measured intranasal volume. Semax's effect on BDNF lasts hours despite the ~2-3 min plasma half-life, which is the basis for once-to-thrice-daily dosing. Commonly run in 10-14 day courses with a break, mirroring the Russian clinical protocols.
Semax: nootropic effects (attention, working memory) typically noticeable within ~30-60 minutes of intranasal administration and lasting ~6-8 hours; BDNF-mediated effects build over 3-8 hours and persist ~24 hours. Selank: anxiolytic effects reported within ~30 minutes to a few hours; benefits tend to accumulate over a multi-day course.
As a standalone dual-purpose nootropic/anxiolytic it needs no companion. In broader stacks it is sometimes explored alongside cognitive-support compounds. Because Selank calms and Semax stimulates, the pairing is intended to be self-balancing; adding further stimulants may tip toward overstimulation.
Log every dose, count every vial, and verify your batches — free in the goodtides app.
This page is educational reference material about compounds studied in research settings. It is not medical advice, and nothing here is a recommendation to buy, possess, or use any compound. Research findings described are from published literature; individual compounds may not be approved for human use. Talk to a licensed clinician about anything that affects your health.