TB-500
TB-500 is a synthetic peptide related to thymosin beta-4, studied for soft-tissue and wound repair, cell migration, and angiogenesis; research protocols typically use about 1 mg twice weekly subcutaneously (range 0.5-5 mg).
It has been studied primarily in preclinical and laboratory settings for soft-tissue and wound repair, cell migration, angiogenesis, and reduction of inflammatory signaling.
TB-500 is a synthetic peptide related to thymosin beta-4 (Tβ4), a naturally occurring 43-amino-acid actin-sequestering peptide that is among the most abundant members of the beta-thymosin family in mammalian tissue. TB-500 contains the actin-binding region (including the LKKTET motif of the WH2 domain) thought to carry much of Tβ4's cell-biological activity. Research has characterized Tβ4 as the major monomeric (G-)actin-sequestering peptide in cells: it binds globular actin monomers and modulates the polymerization dynamics that govern cell shape and motility.
Through these and related actions, preclinical and laboratory studies have explored roles in cell migration, angiogenesis, reduced inflammatory signaling, and soft-tissue and wound repair across dermal, corneal, and cardiac injury models. , RegeneRx programs in ophthalmology and cardiac injury), while TB-500 itself is used as a research compound and is not approved for human use.
In research contexts thymosin beta-4-related peptides are typically administered by subcutaneous injection, and the founder handbook describes an approximately 1 mg every-other-day approach, though no standardized human dosing for TB-500 has been established.
Time-to-effect is not well defined for TB-500 in humans; preclinical models report tissue-repair and migration effects over days to weeks of repeated administration.
It is commonly stacked in research and protocol contexts with BPC-157 for complementary soft-tissue recovery support.
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This page is educational reference material about compounds studied in research settings. It is not medical advice, and nothing here is a recommendation to buy, possess, or use any compound. Research findings described are from published literature; individual compounds may not be approved for human use. Talk to a licensed clinician about anything that affects your health.